What is 2C-B? Effects & Risks

Most amphetamines or other stimulants tend to produce a rapid comedown — which can make users feel depressed. The higher you go over the 15 mg dose, the more likely you are to experience challenging or uncomfortable experiences. The post covid alcohol intolerance hallucinations on 2C-B can escalate very quickly at higher doses. Some could even describe the visuals at higher doses to be “cartoon-like” — which is similar to the visuals experienced with higher doses of mescaline. Most people who use more than 35 or 40 mg of the drug report intense, often scary, or confronting hallucinations. Lower doses of around 5 mg have effects most similar to MDMA or Adderall, while the higher doses (more than 15 mg) offer formidable hallucinogenic effects comparable to LSD, psilocybin, or mescaline.

1. 2C-B isn’t used medically because of its current standing as a Schedule I substance in the United States.
2. The 35 mg dose is a potent psychedelic — and very high doses (50 mg or more) are profoundly psychedelic and have even been known to induce out-of-body experiences.
3. The simplest way to recognize signs of use is through observational study.
4. There have been reports of 2C-B triggering a false-positive on amphetamine tests, but this is very rare.
5. Maximum effects (Emax) and the time needed to reach maximum effects (tmax) were also calculated for the mentioned variables.

These Academics Went Public About Using Drugs

Touch, smell, taste, color, maverick house sober living and sound all tend to be enhanced during this time, and many people report feeling squarely “in the body”—aware of their muscles and nerves and merging with physical nature. Unlike on MDMA, sexual arousal can be maintained throughout the 2C-B experience. With insufflation, the effects are more abrupt and intense but have a significantly shorter duration, while oral usage results in a milder, longer experience. When insufflated, the onset happens very rapidly, usually reaching the peak at about 20–40 minutes and plateauing for 2–3 hours. In a similar manner to other NSPs and some psychedelics, the human pharmacokinetics of 2C-B has not yet been fully resolved. Analysis of oral fluid samples by LC–MS/MS concentrations ranged from 1.43 to 7.73 ng/ml, with an average peak concentration of 4.19 ng/ml observed between 1 and 3 h after administration.

“2C-B is a cheap MDMA substitute”

Regarding 2C-B, as other hallucinogenic phenethylamines, is a partial agonist of 5HT2A, 5HT2B, and 5HT2C receptors (Rickli et al., 2015; Luethi et al., 2017). Other studies however have reported that may act as a 5HT2A full antagonist (Villalobos et al., 2004). It elicits weak response (5–10%) in both phospholipase A2–arachidonic acid (PLA2–AA) release and phospholipase C-inositol phosphate (PLC-IP) accumulation on 5HT2A receptors (Kurrasch-Orbaugh et al., 2003; Moya et al., 2007). The metabolism of 2C-B has been studied in experimental animals and in vivo models (Kanamori et al., 2002, 2005; Carmo et al., 2004; Theobald et al., 2007). It is generally assumed that 2C-B is metabolized mainly by the monoamine oxidase enzymes, MAO-A and MAO-B, and, to a lesser degree, by the CYP450 system (Carmo et al., 2005; Pichini et al., 2008; Kanamori et al., 2013, 2017). Currently, there are not data available describing active metabolites that could contribute to overall effects, therefore, 2C-B seems the active one while the rest are inactive or nearly so.

However, results of 2C-B pharmacokinetics indicate that 2C-B can be detected in oral fluid at very low concentrations up to 16–24 h after self-administration. Unfortunately, the interpretation of 2C-B concentrations in oral fluid is extremely difficult without data from plasma (not performed in this study neither in any study involving humans). By contrast, collection of oral fluid is easy and non-invasive, and was the method selected to obtain pharmacokinetic data in this study. Anecdotally, in two subjects involved in a road accident, 2C-B has been identified in blood at concentrations of 1.6 and 14 ng/ml together with amphetamine (Busardò et al., 2017). Our results showed the highest scores for intensity, volition and affect subscales. Interestingly, the present study found that the HRS scores were similar to those 2C-B ratings reported by recreational psychedelic users.

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In relation to the VESSPA-SP questionnaire, 2C-B induced significant increases compared to baseline in all subscales. The main changes were observed in SOC (pleasure and sociability), ACT (activity and energy), and S (sedation) subscales. Alternatively, you may have a spirit guide or trip sitter—someone who remains sober and monitors your well-being throughout the experience. 2C-B’s anesthetizing effects can also cause severe injuries to go unnoticed, discouraging people from seeking medical attention. A 2015 study in Spain suggested that the drug reduced aggression and encouraged open-mindedness, but the results were inconclusive. To our best knowledge, there have been no scientific studies into the long-term effects of 2C-B use.

How Does 2C-B Impact Mental Health?

Because 2C-B can inhibit one’s spatial coordination and attention span, a space as free from hazards as possible is the ideal setting for an experience. The drug’s mild anesthetic effect can sometimes allow injuries to go unnoticed.1126 Driving is especially dangerous while under the influence and should always be avoided. We’re running a continual survey on the use of 2C-B to better understand the effects and use patterns surrounding this unique psychedelic substance.

2C-B is a novel psychoactive drug that alters a person’s thought process, sense of time, and emotions. Though part of the same family of compounds, 2C-B isn’t the same as 2C-P, the more dangerous drug implicated in the death of Louella Fletcher-Michie at Bestival in 2017. Unlike 2C-B, 2C-P has a history of overdoses dating back to the early-90s – although Fletcher-Michie was the first recorded death – and today is sold by just one darknet dealer. However, it’s still available on the regular internet as a research chemical from legal sites aimed, in theory, at scientists. 2C-B affects the heart rate, blood pressure, and the central nervous system, which could make it unsafe for people with convulsive seizure disorders (e.g. epilepsy), heart problems, diabetes, schizophrenia, or a history of mental illness. Horror stories in sensationalist media have portrayed 2C-B as a deadly, threatening drug.5051 And while its toxicity profile has yet to be fully established, such reports are dubious, to say the least.

People often take it with other psychedelic drugs, increasing the probability of addiction and even alcoholic ketoacidosis smell death. While hallucinogens are not typically addictive, 2C-B’s stimulant effects can lead to addiction, causing long-term negative effects. People may depend on the drug to achieve positive feelings, neglecting aspects of their daily lives to acquire or use it. People diagnosed with a mental illness are more significantly at risk of its adverse effects. Because 2C-B induces psychedelic sensations, many people with an existing mental illness have a greater chance of getting an unpleasant experience. Polydrug use is a term for the use of more than one drug or type of drug at the same time or one after another.